Individual results may vary

"Now that I'm experiencing
fewer attacks, I can finally
focus on other things in my life."
—Mike, patient with AIP

Individual results may vary

"Now that I'm experiencing
fewer attacks, I can finally
focus on other things in my life."
—Mike, patient with AIP

Upcoming programs and events

Join other patients and caregivers as you learn how to navigate acute hepatic porphyria (AHP) treatment together, led by speakers who are experts in the field. Stay up to date with the latest information about GIVLAARI® (givosiran) at an upcoming event below.

Click below to register for an upcoming event.

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Join us for Introduction to GIVLAARI, an educational event presented by an Alnylam Patient Education Liaison that will help you better understand AHP and how GIVLAARI may help. Hear from a patient taking GIVLAARI how having fewer attacks has made an impact, and learn about how patients prescribed GIVLAARI get started.

Introduction to GIVLAARI® (givosiran) for the Treatment of Adults with Acute Hepatic Porphyria (AHP)

Join us for Introduction to GIVLAARI, an educational event presented by an Alnylam Patient Education Liaison that will help you better understand AHP and how GIVLAARI may help. Hear from a patient taking GIVLAARI how having fewer attacks has made an impact, and learn about how patients prescribed GIVLAARI get started.

Register here

Stay informed with educational resources

There is a range of resources designed to help you navigate your treatment journey. Explore all the helpful information provided below.

Considering GIVLAARI brochure

Considering GIVLAARI® (givosiran)?

This brochure will help you learn more about GIVLAARI. If GIVLAARI seems like something that may help you, talk with your doctor about your treatment options.

 

Starting GIVLAARI brochure

Starting GIVLAARI

Now that you and your doctor have decided to start you on GIVLAARI, this guide may help you understand more about your treatment and the support available to you through Alnylam Assist®.

Frequently asked questions about GIVLAARI

There are probably a lot of things you want to know about GIVLAARI. Below you can find some answers to frequently asked questions. This information is not intended to replace discussions with your healthcare provider.

Choose a topic from one of the categories below, and click on it to get more information.

  • GIVLAARI is a prescription medicine used to treat AHP in adults. There are 4 types of AHP:
    • Acute intermittent porphyria (AIP)
    • Variegate porphyria (VP)
    • Hereditary coproporphyria (HCP)
    • ALAD-deficiency porphyria (ADP)
  • Most patients in GIVLAARI clinical studies had AIP, the most common type of AHP

GIVLAARI is given once a month as a subcutaneous injection (under the skin) by a healthcare professional.

If you miss a dose, talk to your doctor about scheduling your next dose as soon as possible.

GIVLAARI can cause liver problems. Your doctor will check your liver function by doing blood tests:

  • Before you start using GIVLAARI
  • Once a month for the first 6 months of treatment
  • And when they think it is needed

If these tests show abnormal results, your healthcare provider will decide whether to temporarily interrupt or stop treatment with GIVLAARI.

GIVLAARI can cause kidney problems. Your doctor will check how your kidneys are working while you are using GIVLAARI.

GIVLAARI may cause increased levels of homocysteine (a type of amino acid ) in your blood. Your doctor will check your homocysteine levels before and during treatment by doing blood tests.

In clinical studies of GIVLAARI, some people on GIVLAARI used hemin to treat AHP attacks. Use of GIVLAARI with regularly scheduled (prophylactic) hemin was not studied in clinical trials of GIVLAARI. Talk to your doctor if you have questions about your treatment plan.

GIVLAARI has not been studied in women who are pregnant. If you are pregnant or plan to become pregnant, it is important to discuss your treatment plan with your doctor.

Keeping a journal to track how you feel is a great way to see if there is progress over time. You can compare your notes from month to month to see any potential changes in your health.

Be sure to bring your journal with you to doctor appointments to remember any questions or share your experience.

GIVLAARI is given as an injection under the skin (subcutaneous) by a healthcare professional. Depending on your doctor’s recommendations and your insurance plan, home administration by a nurse or other healthcare professional may be an option.

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IMPORTANT SAFETY INFORMATION

Do not use GIVLAARI if you have ever had a severe allergic reaction to GIVLAARI.

  • Tell your doctor or nurse right away if you experience any of the following signs or symptoms of a severe allergic reaction during treatment:

    • Swelling – mainly of the lips, tongue or throat which makes it difficult to swallow or breathe
    • Breathing problems or wheezing
    • Feeling dizzy or fainting
    • Rash or hives
    • Itching

    If you have a severe allergic reaction, your doctor or nurse will stop GIVLAARI treatment right away and you may need to take other medicines to control the symptoms.

  • Your doctor will check your liver function by doing blood tests:

    • Before you start using GIVLAARI
    • Once a month for the first 6 months of treatment
    • And when they think it is needed

    If these tests show abnormal results, your doctor or nurse will decide whether to temporarily interrupt or stop treatment with GIVLAARI.

  • Your doctor will check how your kidneys are working while you are using GIVLAARI.

  • GIVLAARI is given as an injection under the skin (called a “subcutaneous injection”). Reactions to this injection may happen during treatment with GIVLAARI.

    Tell your doctor or nurse right away if you experience any of the following symptoms of an injection site reaction during treatment: redness, pain, itchiness, rash, discoloration, or swelling around the injection site.

  • GIVLAARI may cause increased levels of homocysteine (a type of amino acid) in your blood. Your doctor will check your homocysteine levels before and during treatment by doing blood tests. If your levels are increased, your doctor may check your folate, vitamins B12 and B6, and tell you to take a vitamin B6 supplement.

The most common side effects of GIVLAARI are nausea and injection site reactions. These are not all the possible side effects of GIVLAARI. Talk to your doctor about side effects that you experience. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-8 00-FDA -1088.


WHAT IS GIVLAARI® (givosiran)?

GIVLAARI is a prescription medicine used to treat acute hepatic porphyria (AHP) in adults.


For additional information about GIVLAARI, please see full Prescribing Information.